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World's highest resolution microscope gives Lunenfeld scientist a view of the future

World's highest resolution microscope gives Lunenfeld scientist a view of the future

OMX (Optical microscopy eXperimental) microscope

August 5, 2008 - The Samuel Lunenfeld Research Institute at Mount Sinai Hospital is the proud new owner of one of the world’s highest-resolution light microscopes. The only one of its kind in Canada – and one of only three in the world currently – the microscope, called the OMX (Optical microscopy eXperimental) gives scientists the clearest view ever seen of live cells.

“We will be able to see things that we haven’t seen before, and in the long-run better understand how biological processes work,” states Dr. Laurence Pelletier, a Principal Investigator with the Lunenfeld who was approached by microscope manufacturer Applied Precision to help with its development.

Designed by US researcher John Sedat and produced by Applied Precision, the OMX is twice as powerful as the conventional light microscope and can produce ultra-rapid multicolour 3-D images of live cells in real time to study cellular processes in action.

The OMX bridges the gap between a normal microscope and an electron microscope. It uses state-of-the-art lasers and very fast cameras to capture images, guiding light into screen-like grids to illuminate samples with different patterns of light. Using computer algorithms, the extra information gained with the use of structured light results in a direct gain in optical resolution.

Dr. Pelletier will be able to clearly see the microtubules (the structure within cells) and nucleus of a cell in 3D - better understanding a variety of biological systems and helping to unlock some answers to cancer.   

Find out more about Dr. Laurence Pelletier's work »

 
About the Samuel Lunenfeld Research Institute of Mount Sinai Hospital

The Samuel Lunenfeld Research Institute of Mount Sinai Hospital, a University of Toronto affiliated research centre established in 1985, is one of the world’s leading centres in biomedical research. 32 principal investigators lead research in diabetes, cancer biology, epidemiology, stem cell research, women’s and infants’ health, neurobiology and systems biology. For more information on the Samuel Lunenfeld Research Institute, please visit www.mshri.on.ca
 

Contact

Nikki Luscombe 
Communications Specialist 
Samuel Lunenfeld Research Institute of Mount Sinai Hospital
416 586-4800 x 2046
luscombe@mshri.on.ca