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Dr. Katherine Siminovitch, M.D., FRCP(C)

Dr. Katherine Siminovitch is a geneticist who studies the molecular mechanisms underpinning development of immunologic disease. As a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Dr. Siminovitch aims to provide new knowledge and technologies enabling more efficacious and “individualized” therapies for major immunological diseases.


Dr. Siminovitch’s research program is directed at identifying the molecular factors which regulate normal immune responses and which, when disrupted, result in immune deficiency or autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Using both basic research tools and clinical sample sets, Dr. Siminovitch focuses on defining the genetic lesions predisposing to these diseases and the molecular pathways which couple these lesions to cell disfunction and disease.


Dr. Siminovitch is a Professor of Medicine at the University of Toronto and serves as the Director of the Lunenfeld’s Genomic Medicine Program and the Fred A. Litwin Family Centre of Genetic Medicine at Mount Sinai Hospital, and the University Health Network (UHN). She also directs the UHN Gene Profiling Facility and the Toronto General Research Institute Genomic Medicine Division.


In 2005, Dr. Siminovitch was awarded the Canadian Society for Clinical Investigation/Royal College of Physicians and Surgeon of Canada Henry Friesen Research Award. Some of her previous honors include the University of Toronto Dales Award for Medical Research and Institute of Medical Sciences Mel Silverman Mentorship Award, the American College of Rheumatology Henry Kunkel Young Investigator Award and, in 1993, election to the American Society of Clinical Investigation.


Dr. Siminovitch was awarded a Canada Research Chair in Immunogenomics (2005) and has received a CIHR Senior Scientist Award (2000-2005), an Arthritis Society of Canada Research Scientist Award (1992-2001), an Ontario Ministry of Health Cancer Scientist Award (1986-1996) and the Canadian Life and Health Association Medical Scholarship (1986-1992).


She holds an MD from the University of Toronto and is a Fellow of the Royal College of Physicians and Surgeons of Canada in Internal Medicine and Rheumatology.

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